The influence of estrogen deficiency on the structural and mechanical properties of the rat cortical bone
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ID: 0000C1182
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This work describes the changes in the cortical bone of the rat following ovariectomy. We have previously described the unique structure of rat cortical bone, which contains two components: a region with highly organized circumferential-lamellar material and a centrally located region with disordered material. Thisdy evaluates the influence of ovariectomy on these regions separately, using synchrotron based microtomography. Structural features of femoral cortical bone were studied by scanning electron microscopy and synchrotron-based micro-CT. Small cylindrical samples were prepared from the distal shaft of 8 left femora of each group for multi-resolution imaging by monochromatic synchrotron radiation radiography available on BAMline beamline of the BESSY II storage ring of the Helmholtz-Zentrum Berlin für Materialien und Energie (HZB). the entire circumferences of the cortex was scanned at a resolution of 4.35 μm effective pixel size, and the protuberance was scanned at an effective pixel size of 1.75 μm.